sting inhibitor c 176 (MedChemExpress)

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MedChemExpress sting inhibitor c 176
Sting Inhibitor C 176, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 169 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sting+inhibitor+c+176/C-176/pm42157202-65-55-60
Average 97 stars, based on 169 article reviews

sting inhibitor c 176 - by Bioz Stars, 2026-09

97/100 stars

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Article Title: Piezo1 mediates hypoxia-induced endometriosis fibrosis via the mtDNA -dependent cGAS-STING pathway.
Article Snippet: At 60–70% confluency, cells were treated for 24 hours with the specified compounds: the Piezo1 agonist Yoda1 (5 μM; MCE, HY-18723); the Piezo1 inhibitor GsMTx4 (5 μM; MCE, HY-P1410); Ethidium bromide (0.2 μg/ml; Macklin, 1239-45-8) to deplete mitochondrial DNA; the calcium chelator BAPTA-AM (4 μM; MCE, HY-100168); the cGAS inhibitor RU.521(2.5μM, MCE, HY-114180 ); the STING inhibitor C-176 (2.5 μM; MCE, HY-112906); the anti-IL6 antibody (2.5μg/ml, Sigma-Aldrich, I7901); or the ROS inhibitor NAC (2.0mM, MCE, HY-B0215).

Article Title: Ginsenoside Rb1 Targets the HRD1 ‐ STING Axis to Mitigate Cholesterol‐Induced VSMC Senescence
Article Snippet: As depicted in Figure , treatment with the STING inhibitor C‐176 (MCE, CAS No. 314054–00‐7) administered 24 h before other treatments significantly reduced the proportion of SA‐β‐Gal–positive cells, even in the absence of HRD1.

Article Title: DDX41 facilitates PD-L1-mediated immune escape in OSCC via the phase separation and activation STING pathway
Article Snippet: The STING inhibitor C-176 and the p65 inhibitor triptolide were purchased from MCE (C-176 MCE HY-112906, Triptolide HY-32735).

Selection:

Article Title: Ag 2 Se quantum dots neurotoxicity: mitochondrial stress drives ferroptosis-dependent microglial inflammation.
Article Snippet: .. For inhibitor intervention groups, a specific ferroptosis inhibitor Ferrostatin-1 (Fer-1, 500 nM, MedChemExpress, HY-100579, USA), an iron chelator Deferoxamine mesylate (DFOM, 5 μM, MedChemExpress, HY-B0988, USA), a specific STING inhibitor C-176 (1 μM, MedChemExpress, HY-112906, USA), an inhibitor of mPTP opening Cyclosporine A (CsA, 1 μM, MedChemExpress, HY-B0579, USA), a mitochondrial ROS scavenger Mito-tempo (50 μM, MedChemExpress, HY112879, USA) were added to the BV2 cells medium along with 8 μg/mL Ag2Se QDs, respectively and then maintained in the medium for 24 h. The selection ..

Article Title: Ag 2 Se quantum dots neurotoxicity: mitochondrial stress drives ferroptosis-dependent microglial inflammation
Article Snippet: .. For inhibitor intervention groups, a specific ferroptosis inhibitor Ferrostatin-1 (Fer-1, 500 nM, MedChemExpress, HY-100579, USA), an iron chelator Deferoxamine mesylate (DFOM, 5 μM, MedChemExpress, HY-B0988, USA), a specific STING inhibitor C-176 (1 μM, MedChemExpress, HY-112906, USA), an inhibitor of mPTP opening Cyclosporine A (CsA, 1 μM, MedChemExpress, HY-B0579, USA), a mitochondrial ROS scavenger Mito-tempo (50 μM, MedChemExpress, HY-112879, USA) were added to the BV2 cells medium along with 8 μg/mL Ag 2 Se QDs, respectively and then maintained in the medium for 24 h. The selection of inhibitors was based on cell viability assays (Figure S2) and literature reports [ ]. ..

Blocking Assay:

Article Title: Irradiated Liver Cancer Cell Vaccine Transfected With GM-CSF Induces Specific and Long-Lasting Anti-tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM-CSF.
Article Snippet: .. To investigate the effect of blocking STING signalling on BMDCs, mice were immunised with irradiated Hepa 1- 6- mGM- CSF cells with or without intraperitoneally administered STING inhibitor C- 176 (MCE, 13.4 mg/kg) [26]. ..

Irradiation:

Clinical Proteomics:

Control:

Article Title: Aberrant Accumulation of Cell-Free DNA Activates the cGAS-STING-TBK1 Pathway of γδ T Cells to Promote the Inflammatory Responses in Oral Lichen Planus.
Article Snippet: 2.6 Bacteria culture AR TIC LE IN PR ES S 8 The Prevotella melaninogenica (P. melaninogenica) strain ATCC 25845TM was grown on Columbia agar plates supplemented with defibrinated sheep blood (PB003A, Beijing Luqiao, China) under anaerobic conditions at 37°C. .. 2.7 Animal experiments A total of 21 six-week-old C57BL/6 female mice were housed in a specific pathogen-free (SPF) environment and randomly divided into three groups: (1) PBS control, (2) P. melaninogenica only, and (3) P. melaninogenica with the STING inhibitor C-176 (MedChemExpress, NJ, USA). ..

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